Conclusions Myotoxicity induced by ATR and SIM is associated with the reduced GGOH-dependent prenylation of RAP1 protein – New Small-Molecule Inhibitors Neurodegeneration and Neuropathic Pain

Conclusions Myotoxicity induced by ATR and SIM is associated with the reduced GGOH-dependent prenylation of RAP1 protein

Conclusions Myotoxicity induced by ATR and SIM is associated with the reduced GGOH-dependent prenylation of RAP1 protein. Lower myotoxicity is reflected from the respective increase in AKT 1 (S463) and GSK-3(S9) phosphorylation. Geranylgeranyltransferases (GGTs) control myocyte viability through GGOH, which in excess is likely myotoxic. Cytoprotective autophagy is usually elevated in myocytes during myogenesis. Lite … Continue reading Conclusions Myotoxicity induced by ATR and SIM is associated with the reduced GGOH-dependent prenylation of RAP1 protein